Plectin-1

Description

Plectin is a 500kDa cytolinker protein  found in the cytoplasm of mammalian cells. It acts as a scaffold between microfilaments, microtubules and intermediate filaments.

Structure and Function

Plectin exist in cells as several alternatively-spliced isoforms. The structure of plectin is thought to be a dimer consisting of a central coiled coil of alpha helices connecting two large globular domains (one at each terminus). These  globular domains are responsible for connecting plectin to its various  cytoskeletal targets.

Plectin-1 in cancer

Although normally found in the cytoplasm, plectin is expressed on the cell membrane of multiple cancer cells and can therefore be targeted.